Life isn’t meant to be lived in a constant state of fatigue, with regular mood swings, a low sex drive, poor sleep, and the struggle to maintain or lose weight no matter how well you eat or how much you exercise. However, that is exactly what most days look like for men and women with hormone imbalances.
When hormone levels decline due to age, health conditions, or life changes, it can affect your entire well-being.
Whether you’re a man experiencing low testosterone, a woman noticing early perimenopause symptoms, or someone dealing with hormone imbalance due to excessive exercise or restrictive dieting, you understand how these changes significantly impact your daily life and overall health.
In searching for relief, you’ve likely read about hormone replacement therapy (HRT) as a safe and effective solution for hormonal balance. You’ve probably seen countless reviews from people who rave about how it’s given them their life back.
But what you might not understand is that not all hormone therapies are the same.
Some hormone therapy uses hormones that are identical to the hormones your body naturally produces, while others use hormones that are synthetic and chemically altered. In this article, we will tell you about the most effective and natural form of HRT—bioidentical hormone replacement therapy (BHRT.)
We’ll explain bioidentical hormones, their benefits, safety profile, and therapy options. Most importantly, we’ll explain how bioidentical hormones differ from synthetic hormones and why they are often believed to be the superior choice for anyone looking to restore hormone balance.
What is Hormone Imbalance?
Your body produces over 50 different hormones and each plays a vital role in how your body functions. Hormone imbalance happens when your body has too much or too little of certain hormones. Even small changes in these important chemical messengers can significantly impact your health.
Depending on your gender and which hormones are out of balance, symptoms can range from hot flashes and night sweats to weight gain, muscle loss, low sex drive, mood swings, poor sleep, low energy, and more.
If left untreated, hormonal imbalances can also increase the risk of more serious issues such as osteoporosis, cardiovascular disease, cognitive decline, and metabolic disorders.
Some hormone imbalances are temporary and resolve on their own, while others are long-term and typically require ongoing care. Treatment depends on the underlying cause.
While many supplements claim to balance hormones, few have solid scientific backing, which is why most people turn to hormone replacement therapy (HRT) using either synthetic or bioidentical hormones.
HRT can treat many issues and is the gold standard for treating hormonal imbalances, especially long-term imbalances like menopause. In addition to medical treatment, lifestyle changes—like reducing stress, changing your diet, and staying active—can also play a key role in managing hormone imbalances.
What Are Bioidentical Hormones
Many people assume that all hormones used in hormone replacement therapy (HRT) are the same—this is not true. When you receive HRT, you can either be prescribed synthetic hormones or bioidentical hormones.
Bioidentical hormones are artificial hormones made from natural plant sources like soy and yams that are carefully engineered to become chemically identical to the hormones your body naturally produces.
This process makes them virtually indistinguishable from the hormones your body makes. Some are made in bulk by drug companies, while others are custom-made by a pharmacist based on a prescription. These are called compounded bioidentical hormones.
Unlike synthetic hormones, which have a slightly different structure, bioidentical hormones are designed to mirror your body’s natural hormone production. Your body recognizes bioidentical hormones as its own, which many believe results in better outcomes and fewer side effects.
It’s worth noting that while bioidentical hormones are derived from natural plant sources, claims that they are “all-natural” aren’t exactly true. Yes, they are the closest match to human hormones, but they are still synthetic hormones manufactured in a laboratory.
If you see the phrase “all-natural” used when describing bioidentical hormones, it simply means the hormones aren’t lab-created from the beginning. They originally came from natural sources and are then modified in a lab to match human hormones, unlike fully synthetic hormones, which are entirely created in a laboratory with a molecular structure different from your body’s natural hormones.
The most commonly used bioidentical hormones in bioidentical hormone replacement therapy (BHRT) are estrogen, progesterone, and testosterone. The ones you need will depend on which hormones are low, your symptoms, and the root cause of your imbalance.
While symptoms can be very telling that your hormones are not in an ideal range, only a thorough medical evaluation combined with comprehensive blood work that is then reviewed by a qualified medical provider who understands how the endocrine system works can determine what hormones are low and the root cause.
Whether you’re dealing with perimenopause or menopause symptoms, low testosterone, thyroid imbalances, or any other hormone imbalance, when prescribed and monitored by a qualified healthcare provider, BHRT helps restore the hormones you’ve lost in the most effective and natural way possible.
What Is The Difference Between Bioidentical Hormone Therapy and Synthetic Hormone Therapy
While both bioidentical and synthetic hormones aim to correct hormone imbalances and provide symptom relief, research shows their molecular structure and how your body processes them are different.
Bioidentical hormones are derived from plant sources and modified to be chemically identical to the hormones produced by the human body. This molecular matching means they interact with hormone receptors in the same way as your natural hormones.
Synthetic hormones are also effective at binding to hormone receptors but have structural differences from natural hormones. Research has shown these differences can affect how they’re metabolized by the body and their effects on various tissues and systems, leading to different risk profiles. However, more research is still needed to fully understand these differences.
Also, with bioidentical hormones, you have options for customization if you get them from a compounding pharmacy. These hormones are custom-made for each patient and tailored to individual needs in terms of dosage, delivery method, and combination of hormones. You don’t have this option with synthetic hormones. They are usually produced in standardized doses and forms.
While both forms of hormone therapy can provide symptom relief, it’s essential to discuss the benefits and risks of each option with a qualified healthcare provider who can help determine the best approach.
Why Do Some Clinics Still Prescribe Synthetic Hormones?
If bioidentical hormones are believed by some to be better than synthetic, you might wonder why some healthcare providers still prescribe synthetic hormones.
There seem to be several reasons.
For starters, some might be hesitant to prescribe bioidentical hormones over synthetic because the FDA has yet to officially recognize bioidentical as “superior”.
However, that shouldn’t be the only factor medical professionals should consider when evaluating hormone treatment options. Clinical experience, patient outcomes, and ongoing research should also play a role in determining the most appropriate hormone therapy.
Another reason many medical professionals continue prescribing synthetic hormones is simply because it is what they’re most familiar with. However, as research continues to demonstrate the excellent safety profile and effectiveness of bioidentical hormones, we expect more healthcare providers to make the switch.
Then, there is the cost. This is likely the most common reason someone would choose synthetic over bioidentical. Synthetic hormones are more likely covered by insurance and are typically less expensive than bioidentical options.
Cost should never be the deciding factor when choosing hormone therapy.
While synthetic options may seem more affordable upfront, many people find that synthetic hormones don’t offer the same consistency or long-term results, which could lead to additional doctor visits, treatments, and other healthcare costs.
Benefits of Bioidentical Hormone Therapy
The most significant benefit of bioidentical hormone therapy (BHRT) is symptom relief, which varies depending on the hormones your body lacks and the symptoms that result.
For example, after bringing estrogen levels into balance, women may see relief from hot flashes, mood swings, weight gain, and vaginal dryness. If progesterone was lacking, they may experience better sleep, reduced anxiety, and improved mood balance. Men and women who had low testosterone often notice increased sex drive, muscle strength, energy levels, and overall well-being.
Symptom relief aside, here are some more specific potential benefits of BHRT:
More Predictable Responses
Due to their identical structure to natural hormones, bioidentical hormones are recognized by the body in the same way, which may contribute to more natural responses.
Better Symptom Management
Of course, individual results can vary, but many patients report more effective relief from hormone-related symptoms such as fatigue, weight gain, low libido, hot flashes, and brain fog with BHRT compared to standard synthetic hormone replacement therapy.
Well-Studied Safety Profile
Research suggests that when properly prescribed and monitored, bioidentical hormone therapy can be a safe and effective option for managing hormone imbalances. However, as with any medical treatment, regular follow-ups with a healthcare provider are essential to optimize results and minimize risks.
Potentially Fewer Side Effects
Some patients report better tolerance compared to synthetic alternatives, but individual responses vary. Research is ongoing to fully understand the differences in side effect profiles.
Bone Health Support
Estrogen therapy, including BHRT, has been shown to help maintain bone density, which can be particularly important for those at risk of osteoporosis.
Overall Wellness
Many patients report improved quality of life with BHRT, including better energy levels, mood stability, and mental clarity. However, results can vary from person to person, and it’s important to have realistic expectations about what hormone therapy can achieve.
Bioidentical Hormone Therapy Options
Multiple delivery methods are available for bioidentical hormone therapy. While it might seem like they are all equally effective, the way hormones are absorbed and metabolized can vary significantly based on the method used.
Some options provide better dose control, more consistent hormone levels, and fewer side effects than others. Here’s a breakdown of the most common BHT options and some things to consider:
Injections
Injectable bioidentical hormones offer precise dosing and fast absorption, making them a preferred option for most people. They provide steady, consistent hormone levels, reducing the risk of fluctuations that can cause unwanted symptoms.
This method is commonly used for testosterone therapy in men and women, as well as estrogen replacement for women in menopause. Typically, injections are administered once a week, which some people find inconvenient if they have to visit a clinic for each dose.
However, there is always the option to self-administer at home, and it’s much easier than most people expect. With proper guidance from a healthcare provider, self-injection can be a simple, effective way to maintain hormone balance without frequent clinic visits.
Creams & Gels
Topical applications are a convenient, non-invasive way to absorb hormones through the skin. This method is often used for estrogen and testosterone therapy and is popular for those who want to avoid injections.
However, if you are considering topical hormones, it’s important to be aware that absorption might be an issue. Some people may not absorb enough of the hormone for optimal results, while others may absorb too much, leading to inconsistent effects.
Another drawback is that creams and gels require daily application, which can be inconvenient for those who prefer a low-maintenance approach. Additionally, there is a risk of unintentional transfer. If the cream or gel comes into contact with others (such as children or pets) through skin-to-skin contact, they may absorb hormones unintentionally.
If you choose topical hormones, it is important to follow application guidelines carefully, such as washing hands thoroughly after use and allowing the product to fully absorb before skin contact.
Patches
Hormone patches are a popular form of bioidentical hormone therapy, particularly for estrogen. They deliver hormones directly into the bloodstream through the skin, bypassing the digestive system and the liver.
Patches typically only need to be changed once or twice a week, which can be more convenient than daily creams or gels. However, one drawback is that they may not be suitable for people with sensitive skin or those prone to skin irritation.
There is also potential for the patch to fall off, especially in hot, humid conditions or if it is not applied correctly.
Pills
Oral bioidentical hormones are available for some hormones, but because they must pass through the liver before entering the bloodstream, this process can sometimes alter potency and increase the risk of side effects.
For example, oral estrogen is generally not recommended due to an increased risk of blood clots and liver strain. However, this method is commonly used for progesterone therapy since, as it passes through the liver, it is converted into metabolites that have a calming, sedative-like effect, which can help promote better sleep and reduce anxiety.
Pellets
Pellet therapy involves inserting small, slow-release hormone pellets under the skin. While this method is marketed as a “set it and forget it” solution, it comes with significant drawbacks—particularly for women.
One of the biggest drawbacks of pellets is the lack of dose flexibility. Once a pellet is inserted, the dose cannot be adjusted until it dissolves, which can take months. If the dose is too high or too low, you’re stuck with the imbalance (and the side effects that might come with it) until a new pellet is placed.
Women, in particular, may experience negative effects like excessive testosterone conversion (which can cause acne, hair loss, or irritability) due to the difficulty in fine-tuning doses.
Another issue with pellets can be unpredictable absorption. The rate at which the body absorbs pellets can vary, leading to hormone spikes and crashes. Additionally, pellets require a minor surgical procedure for insertion and removal.
Bioidentical Hormone Therapy Safety
When prescribed and monitored by a qualified healthcare provider, bioidentical hormone therapy (BHRT) is believed to be both safe and effective. However, like any medical treatment, there are potential risks and side effects.
While BHRT offers many potential benefits, there is the potential for side effects such as mood swings, bloating, headaches, fatigue, skin irritation, or changes in libido, which are usually temporary and can often be managed with dosage adjustments.
Furthermore, when carefully managed and monitored by a knowledgeable provider, the benefits of restoring hormone balance typically outweigh the risks.
The consequences of leaving hormone imbalances unaddressed—such as an increased risk of osteoporosis, cardiovascular issues, and cognitive decline—are often far more concerning than the potential side effects of properly supervised bioidentical hormone therapy.
The key to safe and effective BHRT is choosing a healthcare provider who specializes in hormone health, personalizes treatment based on your specific needs, and works with a reputable compounding pharmacy that follows strict quality and safety standards.
Proper prescribing and oversight is required to ensure the best results while minimizing risks.
Before starting therapy, comprehensive bloodwork should be performed to assess your hormone levels. Never take hormones without proper lab testing.
From there, your provider should create a customized treatment plan, prescribing only the hormones you need in doses that align with your body’s requirements. Regular monitoring will follow to ensure hormone levels remain balanced, with adjustments made as needed.
Finding Safe, Effective Bioidentical Hormone Therapy Near You
The biggest complaint we hear from patients after starting hormone replacement therapy (HRT) is they wish they had done it sooner. Much of this is likely due to the many myths floating around about HRT (which simply aren’t true.)
If you are showing signs of a hormone balance, don’t wait. You deserve to feel good and look good. Plus, untreated hormone imbalances can lead to bigger health risks. However, you shouldn’t jump on the first hormone replacement therapy deal you see online.
Unfortunately, there are many unqualified providers and questionable online services offering HRT. Remember, hormone therapy is a medical treatment that requires a prescription and proper oversight.
When choosing a hormone therapy provider, always choose a clinic and healthcare provider that is board-certified, specializes in HRT, and has extensive experience with bioidentical hormones.
Be cautious of red flags that could indicate unreliable providers:
- Anyone willing to prescribe hormones without a thorough medical evaluation
- Online-only services that prescribe hormones without proper testing
- Clinics that don’t require regular monitoring or follow-up appointments
- Providers who promise unrealistic results or make extreme claims
- Those who offer significantly lower prices than other local providers
- Clinics that do not use a reputable compounding pharmacy
Relive Health has nationwide clinics staffed with board-certified experts in hormone replacement therapy and bioidentical hormones. We are diligent about only using compounding pharmacies that are well-established and trusted and follow strict quality and safety standards.
Use our clinic locator to find Relive Health in your area and book a consultation. We would love to answer any questions you might have about hormone replacement therapy and help you determine if BHRT is the right choice for you.
