Dermal fillers can enhance lips, smooth deep lines, and even shape your facial contours. The effects can last months, or even a year or more. But what if you want to correct or refine your look, or the results aren’t what you expected, and you want to go back to your natural appearance?
With other cosmetic injections like neurotoxins (Botox, Dysport, Xeomin), you would have to wait until the product naturally fades, but that’s not the case with dermal fillers. There are dissolvers that have a relatively immediate effect.
Often, with just one quick corrective treatment, a trained injector can use an enzyme solution to safely break down the product and clear it from your body.
This expert guide explains how dissolving filler works, reasons why you might want or need to have your filler dissolved, and what to expect during and after the procedure.
We’ll also go over which fillers can and can’t be dissolved, and answer some of the most common questions about fillers, including if dissolving filler is safe, how much it costs to get your filler dissolved, if dissolving filler hurts, and more!
What Is Dermal Filler Dissolver?
A filler dissolver is an injectable protein enzyme called hyaluronidase that breaks down hyaluronic acid (HA) fillers. Depending on what brand of dissolver your provider uses, you may hear it referred to as Hylenex, Vitrase, or Amphadase.
Dermal filler dissolver is used when someone wants to refine or correct previous HA filler results. This could be because you got too much filler and want to reduce volume, need to address asymmetry, smooth lumps, correct areas where filler has shifted, or simply want to return to your natural baseline without waiting for the filler to naturally break down on its own. Beyond correcting and refining, hyaluronidase is also essential for managing a rare emergency that can occur during filler placement, known as vascular occlusion.
Your body actually naturally produces the active ingredient in filler dissolver (hyaluronidase), but it’s not the same as the hyaluronidase enzyme used to dissolve filler.
- Filler Dissolver Hyaluronidase: The product used in aesthetics is a purified and concentrated lab-created form of hyaluronidase. It is administered in high, localized doses to break down synthetic hyaluronic acid fillers that are designed to resist the body’s natural breakdown process for many months.
- Naturally Occurring Hyaluronidase: The natural hyaluronidase enzyme in your body is produced naturally in several major organs (especially the liver and kidneys), the testes (where sperm are made), and skin tissue. It’s also made by certain immune cells to help them move through your body. Natural hyaluronidase operates in a continuous, balanced cycle to regulate the turnover of your own hyaluronic acid, supporting healthy connective tissue.
The natural biological role of hyaluronidase in the body led researchers to begin studying the enzyme for medical use more than sixty years ago. This resulted in the enzyme being approved by the FDA for various medical applications and eventually being used off-label as a safe and trusted option for dissolving HA-based dermal fillers in aesthetics.
How Does Filler Dissolver Work?
When dissolver is injected into the area where unwanted hyaluronic acid (HA) filler is located, the active ingredient, a protein enzyme called hyaluronidase, begins working immediately, breaking apart the bonds that keep the injected filler gel structured in the tissue.
Hyaluronidase also dissolves a small amount of your body’s own natural HA, but this is a temporary effect and nothing to worry about. Research indicates that the body naturally replenishes its own HA within approximately 15-24 hours, without negatively impacting skin quality.
As the filler breaks down, the body continues clearing the fragmented material over the next several days. The filler dissolver does not stay in your body. Once it has broken down the filler into smaller fragments, your body naturally absorbs and clears the remaining material through normal metabolic processes.
While the effects of the hyaluronidase dissolver are relatively instant, mild swelling may occur after treatment. This typically settles within 24-48 hours, and the early improvements become more visible as the tissue calms. However, the full visual result of dissolving filler can take up to two weeks to fully develop.
It’s important to note that hyaluronidase only works on HA-based fillers, such as Juvederm and Restylane. It does not dissolve biostimulatory fillers like Radiesse or Sculptra, because those products are made from different materials that respond to different biological pathways.
Does Dermal Filler Dissolve On Its Own, and Should You Wait or Dissolve It?
Whether you should wait for filler to fade on its own or choose to dissolve it depends on your goals and how quickly you want to see a change. Hyaluronic acid (HA) dermal fillers do break down on their own, but the process is gradual.
The timeline varies widely depending on the type of filler, the area treated, the amount used, and individual metabolic factors. Most HA fillers last several months, and some can remain visible for a year or longer before fully breaking down.
Choosing to dissolve HA filler is a faster option. Instead of waiting months for the filler to fade naturally, hyaluronidase accelerates the process by instantly breaking down the HA gel, allowing the body to clear it more efficiently and offering almost instant softening of the treated area.
Common Reasons for Dermal Filler Reversal
There are several reasons why someone might choose to dissolve dermal filler, ranging from minor aesthetic adjustments to resolving medical complications.
- Overfilling: Sometimes, the final result of filler can be more dramatic than anticipated, leading to a look that feels unnatural or puffy. Dissolving filler is faster than waiting for it to naturally break down over several months.
- Asymmetry: Even with a skilled injector, minor asymmetries can occur, where one side of the face appears different from the other. If you do not want more filler added to balance the area, dissolving filler where the excess volume sits can help restore a more even appearance.
- Filler Migration: In some cases, a filler may shift from its original injection site, causing fullness in an unintended area. Dissolving the migrated filler can return the area to its natural contour.
- Persistent Lumps or Nodules: Small bumps can sometimes form at the injection site. Dissolving can break down the filler that is creating the uneven texture.
- Discoloration: A subtle bluish tint can occur if filler is placed too superficially in the skin, known as the Tyndall effect. This is different from minor bruising, which gradually fades as the bruise heals.
- Vascular Occlusion: A rare but serious emergency where filler blocks a blood vessel. Immediate dissolution with high doses of hyaluronidase is critical if vascular occlusion occurs to prevent tissue damage.
Sometimes, there isn’t anything “wrong” with the filler at all. Some people simply change their minds and want to go back to their natural baseline, but don’t want to wait for the filler to fade on its own.
Benefits of Filler Dissolver Injections
Dissolver injections can correct unwanted filler results and refine your look by breaking down excess or misplaced product, allowing you to quickly return to your natural appearance. They offer a safe and effective way to address concerns like asymmetry, overfilling, or visible lumps without waiting months for filler to fade on its own.
Other benefits of dermal filler dissolver include:
- Simple and straightforward: A medical-grade hyaluronidase solution is injected directly into the areas with unwanted filler. The process is very similar to receiving a standard filler injection.
- Quick results: The enzyme in filler dissolver begins working right away, and early softening and volume reduction often become noticeable within the first day or two as swelling subsides.
- Non-invasive: Dissolving filler is just a simple injection. No incisions or surgical steps are required.
- Minimal downtime: Most people resume normal activities the same day or within 24 hours of getting filler dissolved.
- Versatile: Lips are a popular area for dissolving filler, but dissolvers can be used in any area where hyaluronic acid filler has been placed, such as cheeks, under-eye hollows, and jawline.
What to Expect When Getting Your Dermal Filler Dissolved
Many people are nervous about dissolving their filler. But once you understand how simple and straightforward the process is, it becomes less intimidating.
Dermal Filler Dissolver Consultation
Every filler correction begins with a thorough consultation. This is an opportunity to discuss your concerns and goals with an injector experienced in dissolving fillers.
They will assess the area of concern, review your treatment history, and determine the best course of action. They will also ask about your medical history and if you have any allergies. This is important because, for example, if you have an allergy to bee stings, this can indicate a higher risk of an allergic reaction to the active ingredient in filler dissolver.
If dissolving filler is your next best step, you can often have it done during the same visit. Or, if you prefer to take some time to think about your options, you can schedule your appointment for a later date.
The Dermal Filler Dissolving Procedure
To ensure your comfort, a topical numbing cream is applied to the treatment area beforehand. Once you are numb, your provider will use a very fine needle to inject the hyaluronidase solution into the precise locations where the filler needs to be dissolved.
The filler dissolving procedure is typically very quick and is usually completed in 15-30 minutes.
Recovery From Dissolving Dermal Filler
Recovery after dissolving filler is generally mild. Most people feel comfortable returning to normal daily activities the same day or the following day.
You may experience temporary swelling, redness, tenderness, or light bruising around the treated area. These reactions are expected as the enzyme works and the tissue responds. Swelling often peaks within the first day or two and then begins to settle.
You may also notice that the treated area appears slightly uneven or fuller immediately after the procedure. This is typically due to swelling and improves as the tissue calms and the body clears the dissolved filler fragments.
Potential Side Effects of Filler Dissolver
Dissolving filler is generally safe, with only mild side effects that typically subside quickly. Common temporary side effects include swelling, redness, bruising, or tenderness at the injection site. Mild itching can also occur.
Serious allergic reactions are rare but possible, which is why reviewing your medical history during the consultation is important.
Aftercare Guide: Ensuring a Smooth Recovery After Dissolving Filler
Proper aftercare is essential for minimizing side effects and ensuring a smooth, quick recovery. Your injector will provide personalized aftercare instructions. But typically, aftercare centers on keeping the area calm, minimizing swelling, and avoiding anything that could disrupt the healing process.
First 24-48 Hours After Dissolving
- Avoid strenuous activity: Refrain from heavy exercise or anything that significantly elevates your heart rate.
- Avoid alcohol: Alcohol can thin the blood and increase bruising.
- Avoid touching the area: Do not rub, massage, or apply pressure to treated areas unless your provider specifically instructs you to do so.
- Apply ice and arnica: You can use a cold compress intermittently to help reduce swelling and bruising. Arnica cream is also commonly recommended to support the healing process.
- Avoid heat exposure: Stay away from saunas, hot yoga, tanning beds, and direct heat on the treated area, as heat can increase swelling.
- Sleep elevated: Sleeping with your head slightly elevated helps reduce swelling during the first night or two.
After the First Two Days
- Monitor: Some lingering swelling, tenderness, or unevenness may be normal as your body continues to clear the dissolved filler fragments. This should steadily improve. You may continue using ice or arnica during this time if they are helpful. However, increasing redness, spreading warmth, or significant pain are not typical and should be reported to your provider.
- Massage: If your provider gave you any massage protocols, this is when you would begin them, but only if specifically instructed.
- Do not get new filler (yet): It is recommended to wait at least two weeks after dissolving the old filler before getting new filler injections. This allows the tissues to settle, ensuring that you and your provider can accurately assess the final result.
Following your provider’s aftercare instructions is the best way to ensure a smooth recovery and the best final result. To learn more about getting the best results from dermal fillers in general, read “Dermal Filler Do’s and Don’ts.”
Dermal Filler Results: Is Dissolving Dermal Filler Instant?
Dermal filler reversal begins immediately, and many people notice a rapid reduction in unwanted volume. However, slight initial swelling can temporarily hide some of the early changes. It is also normal to see mild unevenness or small bumps during the settling phase.
These changes resolve as swelling subsides and the enzyme completes its work. Here is a breakdown of the typical filler reversal timeline:
- Immediately After Dissolving (0 to 48 hours): Swelling, redness, and possible bruising are common. The area may even look temporarily fuller due to swelling. Early softening or reduction in filler often becomes noticeable within this window.
- The First Week After Dissolving: Swelling and bruising continue to improve. Uneven areas gradually smooth as the tissue settles and the body clears the dissolved filler fragments.
- Two Weeks After Dissolving: Most swelling has resolved. The final result is typically visible as the area returns to its natural baseline.
These timelines can vary depending on the type and amount of filler, the area treated, and how your body responds to the enzyme.
Before and After Dermal Filler Dissolver: The Importance of Having Realistic Expectations for Your Results
One of the most common questions patients have is: “If I get my filler dissolved, will my face look exactly the same as it did before I had fillers?” Yes! Your face should look the same if you work with a qualified injector who is experienced in both dermal filler placement and dermal filler correction.
However, it is important to have patience and realistic expectations. There could be temporary swelling that makes the area look fuller or uneven at first.
Additionally, while a filler dissolver is designed to remove only unwanted hyaluronic acid (HA) filler, hyaluronidase may also dissolve some of the body’s naturally occurring HA.
This may cause the treated area to look thinner or show fine lines that were previously plumped by the filler. This is temporary. Once your body replenishes its own HA, which usually takes no more than a day, the skin should return to its normal texture and fullness.
It is also important to understand what those in medical aesthetics refer to as the all-or-nothing reality of dissolving.
Often, patients request that only a small amount of filler be dissolved. However, because the hyaluronidase enzyme is a liquid that spreads through the tissue, achieving extremely precise spot dissolving can be challenging.
For this reason, it is often best to approach filler dissolving with the mindset of a full correction in the originally treated area.
Frequently Asked Questions About Dermal Filler Dissolving
Does dissolving filler hurt?
Most patients report only mild discomfort, similar to that experienced with the initial filler injection. A topical numbing cream is applied beforehand to minimize any pain.
How much does filler dissolver cost?
According to national data, the cost of a single session of filler dissolution typically ranges from $200 to $900. However, the price of dissolving filler can vary based on several factors, including the amount of product needed, the complexity of the case, the provider’s expertise, and your geographic location.
While dermal filler can usually be dissolved in one session, some cases may require more than one treatment to achieve complete removal, which would also affect the total investment. The best way to determine the exact cost for your specific needs is to schedule a consultation with a qualified provider. They can assess the area and provide a personalized quote based on a comprehensive treatment plan.
Does dermal filler dissolver work on all fillers?
No. Hyaluronidase is only effective on HA fillers, which include popular brands like Juvéderm® and Restylane®. Fillers made from materials other than hyaluronic acid, such as calcium hydroxylapatite (Radiesse®) or poly-L-lactic acid (Sculptra®), cannot be dissolved by any available enzyme, including hyaluronidase. For these fillers, the only option is to wait for them to be naturally metabolized by the body over time (months to years). In rare cases, surgical options might be explored.
Can I dissolve fillers at home or naturally?
Your body will naturally break down dermal filler over many months, but you should not attempt to dissolve your filler at home. Dissolving fillers with hyaluronidase is a medical procedure that should only be performed by a licensed and experienced healthcare provider. There are no proven safe or effective methods for dissolving HA fillers at home.
Are there any alternatives to dermal filler dissolvers?
There are other approaches for managing filler-treated areas, but none are direct dissolvers in the same sense as hyaluronidase. For example, sometimes your provider can carefully use manual massage to redistribute a fresh filler lump. Some patients have also reported seeing mild filler breakdown after professional laser treatments.
There are also topical “dissolver” creams that contain an enzymatic complex (including hyaluronidase, lipase, and protease) that some professionals use to attempt to topically shape and reduce unwanted surface hyaluronic acid. They can sometimes create a subtle softening of very superficial irregularities, but they do not penetrate deeply enough to dissolve injected dermal filler.
Does saline break down dermal filler?
No. You should never attempt to “dissolve” dermal filler using saline. This is a social media trend. Saline does not break down the HA molecule. It may temporarily disperse the product, but even then, the effects would be minimal.
How many sessions does it take to dissolve dermal filler?
For most patients, a single dermal filler dissolving session is typically enough. However, for larger volumes of filler or more complex cases, a second session may be necessary to achieve complete removal.
Is hyaluronidase safe?
Yes, when administered by a qualified professional, hyaluronidase is considered a very safe treatment. However, it is important to note that all brands of hyaluronidase (Hylenex®, Vitrase®, Amphadase®, Hydase®) are not FDA-approved for dissolving filler. They are only approved as prescription medicines for specific medical uses.
For the cosmetic purpose of dissolving dermal fillers, hyaluronidase is considered an “off-label” use. That doesn’t mean it’s not safe. The use of hyaluronidase for dissolving HA fillers is a widespread, accepted, and often necessary standard of care in aesthetic medicine, despite not having a specific FDA indication for that purpose.
Can you dissolve filler in the cheeks, under the eyes, and jawline?
Absolutely. Hyaluronidase can be used to dissolve HA fillers in any area they are injected, including the lips, cheeks, under-eye area (tear troughs), jawline, and nasolabial folds.
The Importance of Carefully Choosing Who Performs Your Filler Correction
Choosing the right provider for filler correction is just as important as choosing the right filler and injector for the initial procedure. Dissolving filler may seem simple, but it requires training, precision, and a strong understanding of facial anatomy.
The goal when dissolving filler is to remove only the unwanted filler while protecting the surrounding tissues and ensuring a smooth, natural-looking result. To safely achieve this, technique, dosage, and placement matter.
A qualified provider knows how the enzyme spreads, how different fillers behave in different areas of the face, and how to minimize the risk of over-dissolving or uneven correction.
Ready to Dissolve Your Filler? Schedule a Consultation at Relive Health
If you are considering dissolving filler and want expert guidance on the best way to return to your natural baseline, at Relive Health Centers nationwide, our injectors are trained in safe and effective filler correction.
We use a careful, individualized approach, whether you are refining a small area or starting fresh for a new aesthetic direction. Our focus is always on patient-centered care, clear communication, and outcomes that look natural and balanced.Use our clinic locator to find a Relive Health Center near you and schedule a consultation with one of our aesthetic providers to find out if dissolving your dermal filler is the most appropriate path to the results you want.
