Over the years, supplement and pharmaceutical companies have released products that claim to assist with weight loss. However, historically, many of these products have failed to deliver on their promises. They have proven to be ineffective and, in some cases, have even been banned due to safety concerns.
In more recent years, there have been significant advancements in medicine, leading to the development of newer and safer weight-loss drugs that are proving to be very effective for those who struggle to lose weight and, especially, in trying to manage America’s obesity epidemic.
The FDA has approved numerous medications for obesity and weight management that are worth it. In this article, we will go over everything you need to know to help you decide for yourself if newer weight loss drugs like Semaglutide are worth it, including:
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- What weight loss drugs are and how they work.
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- The benefits of medical weight loss drugs.
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- Potential side effects of medical weight loss drugs.
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- How to determine if a medical weight loss drug is right for you.
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- Things to consider before taking a medical weight-loss drug.
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- Where to get prescribed a safe and effective medical weight-loss drug.
What are Weight-Loss Drugs?
Weight-loss drugs cover a large category of prescription medications or dietary supplements formulated with ingredients believed to support fat loss.
Dietary supplements use natural herbs and claim to aid in weight loss. However, they are not regulated by the FDA, often have uncertain efficacy, and are not typically used to treat severe weight conditions such as obesity.
Then, there are medical weight loss drugs like Semaglutide, which have undergone rigorous testing and are approved by the FDA, ensuring safety and effectiveness when used as prescribed. These medications aren’t something you can grab off the internet or pick up at your local pharmacy; they require a doctor’s approval and supervision.
Each medical weight-loss product works differently to promote fat loss. For example, some weight-loss drugs suppress appetite, while others regulate blood sugar levels or alter how the body digests and absorbs nutrients. There are even medical weight-loss drugs like Semaglutide, which work in multiple ways to aid in fat loss.
Semaglutide works by mimicking a hormone in the body called GLP-1, which helps regulate insulin production, lower blood sugar levels, and reduce appetite. When paired with a balanced diet and regular exercise, Semaglutide can aid in weight loss for those who are overweight or obese and may also lower the risk of heart disease, diabetes, and cancer.
Currently, Semaglutide is the drug of choice for medical weight loss. In 2023, semaglutide prescriptions surged, with 1.7% of Americans using the medication—a dramatic 40-fold increase over the past five years. Semaglutide is available as a stand-alone injection and is also the active ingredient in weight-loss medications such as Ozempic, Rybelsus, and Wegovy.
Benefits of Medical Weight-Loss Drugs
If you have had numerous failed attempts at losing weight, are obese, or are facing significant health challenges due to your weight, prescription weight-loss drugs can be a valuable and often life-saving tool that can significantly help you lose weight.
When used alongside lifestyle and behavioral changes, such as adopting a healthy diet, developing a healthy relationship with food, and increasing physical activity, weight-loss medications such as Semaglutide can help people achieve and maintain significant weight loss.
According to the National Institute of Diabetes and Digestive and Kidney Diseases, studies have shown that adults who incorporate prescription weight-loss drugs into their lifestyle programs tend to lose 3% to 12% more of their starting body weight within a year compared to those who rely solely on lifestyle changes.
Even better, most of this weight loss typically occurs within the first six months of starting the medication. Achieving weight loss of this magnitude can bring about significant mental and physical health benefits.
Some of the key benefits of medical weight loss drugs include:
A “Kick-Start” Often Needed for Motivation
It can be discouraging when you diet and exercise, and the pounds and inches take forever to come off, you hit plateaus, or even worse, you don’t really see results at all. In contrast, when you see the number on the scale go down, your clothes start fitting looser, or you experience other non-scale weight-loss victories, it can motivate you to push harder and stick to the plan.
Because medical weight loss drugs often work quickly and drastically, they can provide the early motivation boost many need to encourage themselves to stick to the lifestyle changes that are needed to enhance and sustain results.
Medically Supervised
When taking weight-loss medication such as Semaglutide, you are under the guidance of a medical professional with expertise in weight loss. They will not only evaluate you to determine if a medical weight loss drug is right for you and in the correct dosage, but you will also receive ongoing medical observation throughout the course of your treatment.
Having a medical expert involved in your weight-loss journey from start to finish ensures that you are doing things safely, progressing properly, and addressing any questions or possible side effects should they occur along the way.
Enhanced Weight Loss
Prescription weight-loss medications can help you lose a higher percentage of your starting weight compared to lifestyle changes alone, leading to more noticeable results. This is especially beneficial for someone who has a significant amount of weight to lose.
Improved Metabolic Health
Medical weight-loss drugs like Semaglutide can significantly enhance metabolic health. While Semaglutide does not directly alter the body’s metabolic adaptation to weight loss, it can indirectly influence metabolic processes by changing appetite, improving blood sugar levels, and promoting better body composition.
These factors are essential if you want to lose weight and keep it off. Regulating blood sugar helps prevent energy crashes and reduce cravings, making it easier to maintain a healthy diet and consistent energy levels. Additionally, improving body composition by increasing muscle mass and reducing fat can boost the overall metabolic rate, making weight loss more sustainable.
Improved Blood Pressure and Triglyceride Levels
One of the best benefits of losing weight with medical weight-loss drugs is the positive effect on blood pressure and triglyceride levels. As you shed excess weight, you will often experience reductions in both systolic and diastolic blood pressure, lowering the risk of hypertension-related complications.
Additionally, weight loss can decrease triglyceride levels, which helps reduce the risk of cardiovascular diseases and improves overall heart health.
Joint Pain Relief
Excess weight can put significant strain on your joints, particularly the knees, hips, and lower back. This added pressure often leads to discomfort and pain, limiting mobility and making even the smallest daily activities more challenging.
By losing weight, you can alleviate this strain, which may lead to noticeable reductions in joint pain. Improved joint health enhances comfort and makes it easier to stay active, which is a huge contributor to weight loss and an overall healthier lifestyle.
Better Sleep Quality
Weight loss can significantly enhance sleep quality, particularly for individuals suffering from conditions such as sleep apnea. Improved sleep quality enhances daily functioning and energy levels, meaning you will have more energy to engage in physical activities, focus on daily tasks, and maintain a healthier lifestyle.
Lack of sleep can also throw off your hunger hormones and cortisol levels. Both of these can lead to increased cravings for unhealthy foods and difficulties in managing stress, potentially sabotaging your weight loss efforts and overall health.
Psychological Benefits
Medical weight-loss drugs can also offer significant mental health benefits. Achieving weight loss can improve self-esteem and body image, leading to a more positive outlook and reduced feelings of weight-related depression or anxiety.
As people struggling with weight notice physical changes and experience improvements in their health, they often gain confidence and a greater sense of control over their lives, contributing to a more positive and healthy emotional well-being.
Can be a Life-Saving Intervention
In certain cases, medical weight-loss drugs could save your life. Most people who are severely overweight or obese have related health conditions such as heart disease, diabetes, or high blood pressure.
Medical weight loss drugs help to drastically reduce weight, often quickly, which can lead to significant health improvements, lowering the likelihood of and potentially curing life-threatening health complications.
Potential Side Effects of Medical Weight-Loss Drugs
Medical weight-loss drugs offer numerous benefits for those struggling with their weight, particularly when combined with healthy lifestyle choices. That said, like any medication, they come with a few potential side effects.
Some of the most common side effects reported from medical weight-loss drugs include:
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- Nausea
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- Headaches
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- Dry mouth
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- Diarrhea
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- Constipation
Generally, if you experience any of these symptoms, they are short-lived and can often be avoided altogether by starting off with a lower dose and slowly increasing it as your body adjusts.
If you do experience side effects, such as persistent nausea, there are alternative medications or adjustments your healthcare provider can recommend to alleviate these symptoms.
It’s important to only work under the guidance of a qualified medical weight-loss expert and have open communication with them about any concerns that you have and any side effects you might experience to ensure that any adverse effects are correctly managed.
Are Medical Weight-Loss Drugs Right for You?
Medical weight loss is for people who need extra support to lose weight in a safe and sustainable way. It’s often recommended when extra weight starts affecting your health or overall well-being. You might be a good fit for a medical weight loss program if:
- You are ready to improve your health. Medical weight loss is most effective when individuals are committed to making lasting lifestyle changes in addition to using prescribed treatments.
- Your weight has caused problems with your health. If excess weight has contributed to conditions such as insulin resistance, heart disease, or mobility issues, medical weight loss may help reduce these risks.
- Your weight has impacted how you feel about yourself. Beyond physical health, carrying excess weight can affect mental well-being, confidence, and overall quality of life. Medical weight loss programs can provide structured support to help you achieve your goals.
If you meet these criteria, working with a healthcare provider can help determine the best medical weight loss strategy for your needs, including prescription medications, lifestyle changes, and personalized nutrition plans.
Who Qualifies for Medical Weight Loss Drugs?
If you’ve struggled to lose weight through diet and exercise alone or have health concerns linked to excess weight, prescription weight-loss medications may be an option. These medications are designed to support weight loss when lifestyle changes alone aren’t enough, particularly for those facing health risks due to their weight.
Before prescribing a medication like Semaglutide, healthcare providers evaluate multiple factors, including:
- Age and Weight Loss Goals – Prescription weight-loss medications are typically approved for adults 18 and older who meet specific medical criteria based on BMI and health risks. While individual weight-loss goals vary, these medications are most effective for those needing significant, sustainable weight loss.
- BMI and Health Conditions – You may qualify for medical weight-loss medications if you have a BMI of 30 or higher, or 27+ with weight-related conditions such as high blood pressure, type 2 diabetes, sleep apnea, or joint problems.
- Your Weight Loss History – If you’ve previously attempted structured diets, exercise plans, or other weight-loss methods without long-term success, medication may provide additional support.
- Metabolic and Health Factors – Certain health conditions, such as insulin resistance, metabolic syndrome, or polycystic ovary syndrome (PCOS), can make weight management more challenging. In these cases, prescription weight-loss drugs may be particularly beneficial.
- Lifestyle and Readiness for Change – Weight-loss medications work best when combined with healthy eating habits and regular physical activity. A strong commitment to long-term lifestyle changes improves overall success and helps prevent weight regain.
- Personalized Risk and Benefit Assessment – Everyone responds differently to weight-loss medications. Your healthcare provider will assess the potential benefits and risks based on your medical history, current health status, and personal goals to determine the best treatment approach.
These medications aren’t a one-size-fits-all solution, but they can provide the extra help needed to reach a healthier weight. A consultation with a qualified healthcare provider will help determine whether a medical weight-loss drug is right for you and how it can be integrated into a sustainable, long-term plan.
It’s important to remember that these drugs should always be used alongside a healthy diet and regular exercise. While they can be an effective tool for weight management, stopping the medication without maintaining lifestyle changes may lead to weight regain.
What Is the Best Way to Medically Lose Weight Beyond Medication
While prescription weight-loss drugs like Semaglutide have gained attention for their effectiveness, they are just one part of the broader medical weight-loss landscape. Depending on individual health needs and weight-loss goals, several other medically supervised options may be worth considering:
- Bariatric Surgery (Weight-Loss Surgery)
For individuals with severe obesity or those who have struggled with long-term weight loss, bariatric surgery can be a life-changing option. These procedures, such as gastric bypass or sleeve gastrectomy, alter the digestive system to reduce food intake and calorie absorption. Candidates typically have a BMI of 40+ or 35+ with obesity-related health conditions like diabetes. Surgery requires long-term lifestyle changes but can result in significant and sustained weight loss.
- Nutrition Counseling & Medically Supervised Diets
For those who need more structured dietary guidance, medical professionals offer customized nutrition counseling to address eating habits, calorie balance, and behavior modification. In some cases, very low-calorie diets (VLCDs) are used under supervision, particularly for individuals who need to lose weight rapidly for health reasons.
- Medically Supervised Meal Replacement Programs
Programs like Optifast and HMR provide nutritionally balanced shakes and meals that help control calorie intake while ensuring adequate nutrition. These are often used in short-term weight-loss plans, with a transition to whole foods for long-term success.
- Intragastric Balloons (Non-Surgical Weight Loss Option)
For those who aren’t candidates for surgery but need more than diet and medication, intragastric balloons provide a temporary, non-surgical tool for weight loss. These balloons reduce stomach capacity, helping individuals feel full faster. They are typically left in place for about six months and can lead to 15–20% total body weight loss when combined with lifestyle changes.
The best medical weight-loss strategy depends on individual health status, weight-loss history, and personal goals. While prescription medications like Semaglutide are highly effective for many, some may benefit more from surgical interventions, structured diet plans, or non-surgical medical tools. Consulting a healthcare provider can help determine the safest and most effective approach.
The Most Effective Weight Loss Medications
The most effective weight loss medication depends on your lifestyle, medical history, and overall health goals. Prescription weight loss medications can be powerful tools, but they work best when combined with healthy lifestyle changes, including regular physical activity and a balanced diet.
Here are some of the most effective prescription weight loss medications:
- Phentermine-topiramate (Qsymia): This combination medication can lead to significant weight loss by suppressing appetite and increasing feelings of fullness. It is often prescribed for people with obesity or those struggling with weight-related health conditions.
- Semaglutide (Ozempic, Wegovy): Originally developed for diabetes management, this GLP-1 receptor agonist has been shown to help people lose a substantial amount of weight by slowing digestion and reducing hunger signals.
- Tirzepatide (Zepbound): This medication mimics natural incretin hormones, which help regulate blood sugar and promote weight loss by enhancing the body’s insulin response and reducing appetite.
- Mazdutide (IBI362): An injectable medication that mimics glucagon, Mazdutide is currently being studied for its potential to promote weight loss by increasing energy expenditure and controlling hunger.
- Orlistat (Alli, Xenical): Unlike appetite suppressants, Orlistat works by blocking the enzyme lipase, preventing the body from absorbing dietary fat. This can be a useful option for those looking to reduce calorie intake from fat.
- Setmelanotide: A medication specifically designed for individuals with certain genetic obesity disorders, Setmelanotide helps control hunger and promote fullness by influencing the brain’s appetite regulation system.
Because each person’s body responds differently to weight loss treatments, working with a doctor is essential to finding the most effective and safe approach for your needs. Your healthcare provider can help assess potential side effects, monitor progress, and adjust the treatment plan as necessary.
How to Transition Off Weight Loss Medications
Starting a weight loss medication can be a powerful tool in achieving your health goals, but maintaining your results after stopping them is key. A smooth transition involves strategic planning and long-term lifestyle adjustments. Here’s how to successfully shift away from weight loss medications while sustaining your progress:
Understand Your Medication Plan
Weight loss medications vary in duration—some are meant for short-term use, while others support long-term weight management. Work with your healthcare provider to determine when and how to taper off safely.
Establish Healthy Eating Habits Early
While on medication, focus on building a strong nutritional foundation. A balanced diet will support your metabolism and help prevent weight regain. Prioritize:
- Fruits and vegetables for fiber and essential nutrients
- Lean proteins to support muscle maintenance
- Whole grains for sustained energy
- Healthy fats to promote satiety
Maintain a Consistent Exercise Routine
Physical activity is crucial for long-term weight stability. Establish an exercise habit that fits your lifestyle, whether it’s strength training, yoga, walking, or a mix of activities. The key is consistency—find something you enjoy so it becomes a sustainable habit.
Gradual Step-Down Approach
Stopping medication abruptly can lead to weight fluctuations. Work with your doctor to create a tapering plan that gradually reduces your reliance on medication while reinforcing lifestyle changes.
Monitor Your Progress and Make Adjustments
Track your weight, energy levels, and overall well-being as you transition off medication. Regular check-ins with your healthcare provider can help address challenges and fine-tune your approach to maintaining results.
Successfully maintaining your weight without medication is achievable by prioritizing lasting lifestyle changes. The goal is to build habits that support your health and well-being for the long run.
Things to Consider Before Taking a Medical Weight-Loss Drug
While the research studies and success stories show that weight-loss drugs are worth it for many people struggling with their weight and, especially those experiencing health issues due to obesity, there are things to consider before starting medical weight-loss treatment.
Your Medical History
Before starting any weight-loss medication, it’s crucial that you have a consultation with a weight-loss expert so they can review your medical history. They will evaluate any pre-existing conditions, current medications, and overall health to determine if a weight-loss drug is a safe option for you.
Benefits vs. Risks
Every medication comes with its own set of potential benefits and risks. Weight-loss drugs might come with a few minor side effects; however, they offer significant advantages, particularly when compared to the impacts of obesity.
Obesity itself is linked to a range of serious health issues, including heart disease, diabetes, and joint problems. In this context, the benefits of weight-loss medications—such as substantial weight reduction and improvements in overall health—can far outweigh the risks.
You should discuss any concerns you have with a medical weight-loss expert. They can help you weigh the potential benefits against any possible side effects, ensuring that you make an informed decision about whether or not weight-loss drugs are worth it.
Cost
Cost can be a significant factor when considering weight-loss medications. Insurance may not cover some drugs, leading to substantial out-of-pocket expenses. The cost of medical weight-loss drugs varies depending on geographical location and individual needs. On average, patients may spend several hundred to $1,000 per month for weight-loss injections.
Before dismissing a medical weight-loss drug due to its cost, it’s important to weigh it against the high price of being overweight. Consider the long-term costs of obesity-related health issues, such as chronic conditions, frequent medical visits, and potential loss of quality of life.
Investing in weight-loss medication could potentially reduce these future expenses and improve overall well-being, making it a worthwhile consideration in the context of long-term health and financial savings.
Your Willingness to Adopt and Maintain a Healthy Lifestyle
Taking a weight-loss drug is just one part of the puzzle. For the best results, committing to a healthy lifestyle is essential. This includes making nutritious food choices, staying physically active, and addressing habits that contribute to weight gain, such as poor sleep patterns and not managing stress levels.
A weight-loss medication can provide support, but lasting change comes from consistent, healthy behaviors. If you are not willing to adopt these changes, weight-loss drugs might not be a good option for you, as you will not see the best results, and the weight is more likely to come back as soon as you stop treatment.
Where to get a Prescription for a Medical Weight-Loss Drug
If you’ve been struggling with weight loss, you know how frustrating it can be. You’ve tried diet after diet, exercise routines, and maybe even some questionable “miracle” supplements. Yet, the weight just won’t come off or stay off.
Weight-loss drugs like Semaglutide are giving people hope. However, with their rise in popularity, there’s also been a surge in fake products on the black market. Be wary of online ads, Groupon deals, and sketchy providers that promise prescriptions without a proper medical assessment. These can be scams or sources of counterfeit medications, which can be harmful.
Weight-loss medications require a proper medical evaluation to determine if they’re the right choice for you. Obtaining these drugs without a proper evaluation can be dangerous. It is crucial to only get a Semaglutide prescription from a qualified medical weight-loss clinic like Relive Health.
Our healthcare providers are experienced in prescribing safe and effective weight-loss drugs and will only do so after a proper consultation to ensure you receive the right medication for your needs and that your health is monitored throughout the process.
To find a Relieve Health clinic near you, check out our clinic locator. While you wait for your appointment, we encourage you to learn more about medical weight-loss drugs.
Here are a few articles to get you started:
Semaglutide: Everything You Need to Know
Top 12 Myths about MWL/Semaglutide
